Understanding the marker
SHBG binds hormones such as testosterone in the blood. Its level helps explain how a total testosterone result relates to hormone binding.
A change in SHBG can change the balance between bound and unbound hormones. SHBG is therefore read with testosterone and the reason for testing. Thyroid and liver function, age and hormone treatment can affect the level.
What does high SHBG mean?
High SHBG means more of this binding protein is present. It can affect the interpretation of total testosterone. Related hormones, liver and thyroid results and any treatment provide the context.
What does low SHBG mean?
Low SHBG means less of this binding protein is present. The testosterone result, related tests and any treatment help explain its significance; it does not establish a metabolic or hormonal condition alone.
Panels that measure SHBG
Testosterone Basics
Testosterone Advanced
Men's Health
Women's Hormone Health
Founders Panel Plus
Reading
More markers in the same area
- PSA ratio (free to total)PSA result
- Estradiola form of the hormone estrogen
- Progesteronea hormone that can support evidence of recent ovulation
- FSHa hormone signal to the ovaries or testes
- LHa hormone signal involved in reproductive function
- Testosteronea hormone involved in reproductive and muscle function
This is general information about the marker, not an assessment of your values and not medical advice. Last updated: October 2026.